Assay Detail
Binding
CHEMBL3789014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay
16
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.45 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482081 | — | — | 2 | 5.79 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 2 | 5.75 |
| CHEMBL2312685 | — | — | 2 | 5.31 |
| CHEMBL2312684 | — | — | 1 | - |
| CHEMBL2312682 | — | — | 1 | - |
| CHEMBL2312403 | — | — | 1 | - |
| CHEMBL2312683 | — | — | 1 | - |
| CHEMBL500042 | — | — | 1 | - |
| CHEMBL479804 | — | — | 1 | - |
| CHEMBL482080 | — | — | 1 | - |
| CHEMBL479797 | — | — | 1 | - |
| CHEMBL61997 | — | — | 1 | - |
| CHEMBL372124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482081 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL482081 | — | EC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL2312685 | — | EC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL2312685 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL2312684 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL2312682 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL2312403 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL2312683 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL500042 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL479804 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL482080 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL479797 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL61997 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL372124 | — | EC50 | > | 1000000.0 | nM | - |