Assay Detail
Functional
CHEMBL3789229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against trypomastigote stage of Trypanosoma brucei incubated for 72 hrs by resazurin staining-based fluorescence analysis
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 4.89 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787138 | — | — | 1 | 6.07 |
| CHEMBL3785128 | — | — | 1 | 6.00 |
| CHEMBL218650 | DELAMANID | 4.0 | 1 | 5.77 |
| CHEMBL3785829 | — | — | 1 | 5.66 |
| CHEMBL3786471 | — | — | 1 | 5.51 |
| CHEMBL3188499 | — | — | 1 | 5.47 |
| CHEMBL3787357 | — | — | 1 | 5.41 |
| CHEMBL3785579 | — | — | 1 | 5.38 |
| CHEMBL3787143 | — | — | 1 | 5.28 |
| CHEMBL3787070 | — | — | 1 | 5.05 |
| CHEMBL3785677 | — | — | 1 | 5.05 |
| CHEMBL3787057 | — | — | 1 | 5.04 |
| CHEMBL3786301 | — | — | 1 | 4.92 |
| CHEMBL3786151 | — | — | 1 | 4.92 |
| CHEMBL3786175 | — | — | 1 | 4.80 |
| CHEMBL3787410 | — | — | 1 | 4.70 |
| CHEMBL3787290 | — | — | 1 | 4.48 |
| CHEMBL3785867 | — | — | 1 | 4.48 |
| CHEMBL3785246 | — | — | 1 | 4.48 |
| CHEMBL3786506 | — | — | 1 | 4.48 |
| CHEMBL3787622 | — | — | 1 | 4.47 |
| CHEMBL3786215 | — | — | 1 | 4.42 |
| CHEMBL3785985 | — | — | 1 | 4.40 |
| CHEMBL3786138 | — | — | 1 | 4.30 |
| CHEMBL218974 | — | — | 1 | 4.28 |
| CHEMBL3786795 | — | — | 1 | 4.28 |
| CHEMBL3787314 | — | — | 1 | 4.24 |
| CHEMBL3785947 | — | — | 1 | 4.22 |
| CHEMBL3787306 | — | — | 1 | 4.22 |
| CHEMBL3786769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787138 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3785128 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL218650 | DELAMANID | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3785829 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3786471 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3188499 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3787357 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3785579 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3787143 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3787070 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3785677 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3787057 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3786151 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3786301 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3786175 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3787410 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3787290 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3785867 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3785246 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3786506 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3787622 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3786215 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3785985 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3786138 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3786795 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL218974 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL3787314 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL3785947 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3787306 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3787358 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3785182 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3785572 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3785276 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3786077 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3786950 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3787258 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3787466 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3786335 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3787513 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3785978 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3787254 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3786387 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3785856 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3787018 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3786030 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3786828 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3787439 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3785196 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3785138 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL3786769 | — | IC50 | > | 64000.0 | nM | - |