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Assay Detail

CHEMBL3790032

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Functional
Antitrypanosomal activity against intracellular amastigotes stage of recombinant Trypanosoma cruzi Tulahuen expressing beta galactosidase infected in NIH/3T3 cells assessed as growth inhibition after 4 days by HTS-ready assay
ChEMBL ↗
94
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type NIH/3T3
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368) ↗
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi.
Costa LB, Cardoso MV, de Oliveira Filho GB, de Moraes Gomes PA, Espíndola JW, de Jesus Silva TG, Torres PH, Silva Junior FP, Martin J, de Figueiredo RC, Leite AC.
Bioorg Med Chem (2016) 24 : 1608 -1618
PubMed 26964673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 94 5.49 6.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL90512 — — 1 6.20
CHEMBL3329512 — — 2 6.10
CHEMBL3329522 — — 2 6.05
CHEMBL3786101 — — 2 6.03
CHEMBL3329516 — — 2 6.00
CHEMBL3329511 — — 2 5.98
CHEMBL3785680 — — 2 5.98
CHEMBL2409542 — — 2 5.95
CHEMBL3329523 — — 2 5.90
CHEMBL3329521 — — 2 5.90
CHEMBL3329518 — — 2 5.88
CHEMBL3329517 — — 2 5.87
CHEMBL3329507 — — 2 5.86
CHEMBL3329520 — — 2 5.81
CHEMBL3785717 — — 2 5.79
CHEMBL3329513 — — 2 5.79
CHEMBL3329515 — — 2 5.77
CHEMBL3787052 — — 2 5.75
CHEMBL3329510 — — 2 5.73
CHEMBL3785305 — — 2 5.68
CHEMBL3329504 — — 2 5.66
CHEMBL3329519 — — 2 5.65
CHEMBL3329506 — — 2 5.65
CHEMBL3329508 — — 2 5.64
CHEMBL3786871 — — 2 5.59
CHEMBL3329505 — — 2 5.58
CHEMBL3329509 — — 2 5.57
CHEMBL3785286 — — 2 5.51
CHEMBL3785388 — — 2 5.49
CHEMBL3786510 — — 2 5.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL90512 — IC50 = 630.0 nM 6.20
CHEMBL3329512 — IC50 = 794.33 nM 6.10
CHEMBL3329512 — IC50 = 790.0 nM 6.10
CHEMBL3329522 — IC50 = 891.25 nM 6.05
CHEMBL3329522 — IC50 = 890.0 nM 6.05
CHEMBL3786101 — IC50 = 933.25 nM 6.03
CHEMBL3786101 — IC50 = 930.0 nM 6.03
CHEMBL3329516 — IC50 = 1000.0 nM 6.00
CHEMBL3329516 — IC50 = 1000.0 nM 6.00
CHEMBL3785680 — IC50 = 1047.13 nM 5.98
CHEMBL3329511 — IC50 = 1047.13 nM 5.98
CHEMBL3329511 — IC50 = 1050.0 nM 5.98
CHEMBL3785680 — IC50 = 1050.0 nM 5.98
CHEMBL2409542 — IC50 = 1120.0 nM 5.95
CHEMBL2409542 — IC50 = 1122.02 nM 5.95
CHEMBL3329521 — IC50 = 1260.0 nM 5.90
CHEMBL3329523 — IC50 = 1258.93 nM 5.90
CHEMBL3329521 — IC50 = 1258.93 nM 5.90
CHEMBL3329523 — IC50 = 1260.0 nM 5.90
CHEMBL3329518 — IC50 = 1320.0 nM 5.88
CHEMBL3329518 — IC50 = 1318.26 nM 5.88
CHEMBL3329517 — IC50 = 1348.96 nM 5.87
CHEMBL3329517 — IC50 = 1350.0 nM 5.87
CHEMBL3329507 — IC50 = 1380.38 nM 5.86
CHEMBL3329507 — IC50 = 1380.0 nM 5.86
CHEMBL3329520 — IC50 = 1550.0 nM 5.81
CHEMBL3329520 — IC50 = 1548.82 nM 5.81
CHEMBL3329513 — IC50 = 1620.0 nM 5.79
CHEMBL3785717 — IC50 = 1620.0 nM 5.79
CHEMBL3785717 — IC50 = 1621.81 nM 5.79
CHEMBL3329513 — IC50 = 1621.81 nM 5.79
CHEMBL3329515 — IC50 = 1698.24 nM 5.77
CHEMBL3329515 — IC50 = 1700.0 nM 5.77
CHEMBL3787052 — IC50 = 1778.28 nM 5.75
CHEMBL3787052 — IC50 = 1780.0 nM 5.75
CHEMBL3329510 — IC50 = 1860.0 nM 5.73
CHEMBL3329510 — IC50 = 1862.09 nM 5.73
CHEMBL3785305 — IC50 = 2089.3 nM 5.68
CHEMBL3785305 — IC50 = 2090.0 nM 5.68
CHEMBL3329504 — IC50 = 2190.0 nM 5.66
CHEMBL3329504 — IC50 = 2187.76 nM 5.66
CHEMBL3329506 — IC50 = 2238.72 nM 5.65
CHEMBL3329506 — IC50 = 2240.0 nM 5.65
CHEMBL3329519 — IC50 = 2240.0 nM 5.65
CHEMBL3329519 — IC50 = 2238.72 nM 5.65
CHEMBL3329508 — IC50 = 2290.0 nM 5.64
CHEMBL3329508 — IC50 = 2290.87 nM 5.64
CHEMBL3786871 — IC50 = 2570.0 nM 5.59
CHEMBL3786871 — IC50 = 2570.4 nM 5.59
CHEMBL3329505 — IC50 = 2630.0 nM 5.58