Assay Detail
Binding
CHEMBL3792084
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Inhibition of recombinant c-MET (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.00 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 9.05 |
| CHEMBL3786898 | — | — | 1 | 9.00 |
| CHEMBL3787612 | — | — | 1 | 8.47 |
| CHEMBL3786136 | — | — | 1 | 8.46 |
| CHEMBL3787354 | — | — | 1 | 8.42 |
| CHEMBL3786610 | — | — | 1 | 8.42 |
| CHEMBL3785650 | — | — | 1 | 8.29 |
| CHEMBL3787278 | — | — | 1 | 8.25 |
| CHEMBL3786574 | — | — | 1 | 8.23 |
| CHEMBL3786217 | — | — | 1 | 8.22 |
| CHEMBL3786924 | — | — | 1 | 8.12 |
| CHEMBL3785213 | — | — | 1 | 8.01 |
| CHEMBL3785800 | — | — | 1 | 7.96 |
| CHEMBL3787308 | — | — | 1 | 7.80 |
| CHEMBL3786658 | — | — | 1 | 7.72 |
| CHEMBL3786588 | — | — | 1 | 7.71 |
| CHEMBL3417482 | — | — | 1 | 7.70 |
| CHEMBL3785106 | — | — | 1 | 7.47 |
| CHEMBL3786146 | — | — | 1 | 7.37 |
| CHEMBL3787185 | — | — | 1 | 7.32 |
| CHEMBL3786753 | — | — | 1 | 7.03 |
| CHEMBL3787205 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3786898 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3787612 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3786136 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3787354 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3786610 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3785650 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL3787278 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3786574 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3786217 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3786924 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3785213 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3785800 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3787308 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL3786658 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL3786588 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL3417482 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3785106 | — | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL3786146 | — | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL3787185 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL3786753 | — | IC50 | = | 93.6 | nM | 7.03 |
| CHEMBL3787205 | — | IC50 | = | 105.1 | nM | 6.98 |