Assay Detail
Functional
CHEMBL3794693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KMS11 expressing luciferase gene after 72 hrs by cell titer glo-based cell viability assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KMS-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.30 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3651966 | LGH-447 | 1.0 | 1 | 6.77 |
| CHEMBL3792736 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3651966 | LGH-447 | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3792736 | — | EC50 | = | 1500.0 | nM | 5.82 |