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Assay Detail

CHEMBL3800917

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Novel nucleoside-based antimalarial compounds.
Zheng Z, Tran HA, Manivannan S, Wen X, Kaiser M, Brun R, Snyder FF, Back TG.
Bioorg Med Chem Lett (2016) 26 : 2861 -2865
PubMed 27156774 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.29 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3799107 1 6.24
CHEMBL3797714 1 5.82
CHEMBL3799380 1 5.68
CHEMBL3800393 1 4.62
CHEMBL3798486 1 4.07
CHEMBL3798154 1 -
CHEMBL3800167 1 -
CHEMBL3800544 1 -
CHEMBL3799800 1 -
CHEMBL3799313 1 -
CHEMBL3797278 1 -
CHEMBL3799415 1 -
CHEMBL3799622 1 -
CHEMBL3797375 1 -
CHEMBL3797972 1 -
CHEMBL3797470 1 -
CHEMBL3799049 1 -
CHEMBL3799739 1 -
CHEMBL3798326 1 -
CHEMBL3799944 1 -
CHEMBL3799043 1 -
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL3800333 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3799107 IC50 = 580.0 nM 6.24
CHEMBL3797714 IC50 = 1500.0 nM 5.82
CHEMBL3799380 IC50 = 2100.0 nM 5.68
CHEMBL3800393 IC50 = 24000.0 nM 4.62
CHEMBL3798486 IC50 = 85000.0 nM 4.07
CHEMBL3798154 IC50 = 271000.0 nM -
CHEMBL3800167 IC50 = 110000.0 nM -
CHEMBL3800544 IC50 = 137000.0 nM -
CHEMBL3799800 IC50 = 338000.0 nM -
CHEMBL3799313 IC50 = 188000.0 nM -
CHEMBL3797278 IC50 = 178000.0 nM -
CHEMBL3799415 IC50 = 181000.0 nM -
CHEMBL3799622 IC50 = 236000.0 nM -
CHEMBL3797375 IC50 = 147000.0 nM -
CHEMBL3797972 IC50 = 153000.0 nM -
CHEMBL3797470 IC50 = 266000.0 nM -
CHEMBL3799049 IC50 = 159000.0 nM -
CHEMBL3799739 IC50 = 137000.0 nM -
CHEMBL3798326 IC50 = 120000.0 nM -
CHEMBL3799944 IC50 = 236000.0 nM -
CHEMBL3799043 IC50 = 111000.0 nM -
CHEMBL76 CHLOROQUINE IC50 = 120000.0 nM -
CHEMBL3800333 IC50 = 177000.0 nM -