Assay Detail
Binding
CHEMBL3801702
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Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain cortex incubated for 15 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-HT2 receptor affinity, docking studies and pharmacological evaluation of a series of 1,3-disubstituted thiourea derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.55 | 10.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617113 | — | — | 1 | 10.37 |
| CHEMBL1404528 | — | — | 1 | 9.22 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 9.07 |
| CHEMBL3797474 | — | — | 1 | - |
| CHEMBL3798961 | — | — | 1 | - |
| CHEMBL3617211 | — | — | 1 | - |
| CHEMBL3798863 | — | — | 1 | - |
| CHEMBL3798450 | — | — | 1 | - |
| CHEMBL3799209 | — | — | 1 | - |
| CHEMBL3797981 | — | — | 1 | - |
| CHEMBL3799165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617113 | — | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL1404528 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL51 | KETANSERIN | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL3797474 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3798961 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3617211 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3798863 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3798450 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3799209 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3797981 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3799165 | — | Ki | > | 10000.0 | nM | - |