Assay Detail
Binding
CHEMBL3811630
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Inhibition of ovine COX1 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.55 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.16 |
| CHEMBL3809863 | — | — | 1 | 6.52 |
| CHEMBL3810167 | — | — | 1 | 5.52 |
| CHEMBL3809120 | — | — | 1 | 5.52 |
| CHEMBL3809156 | — | — | 1 | 5.22 |
| CHEMBL3808627 | — | — | 1 | 5.10 |
| CHEMBL3809958 | — | — | 1 | 5.05 |
| CHEMBL3809328 | — | — | 1 | 5.00 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.82 |
| CHEMBL3809116 | — | — | 1 | - |
| CHEMBL3810371 | — | — | 1 | - |
| CHEMBL3809842 | — | — | 1 | - |
| CHEMBL3809922 | — | — | 1 | - |
| CHEMBL3809163 | — | — | 1 | - |
| CHEMBL3808774 | — | — | 1 | - |
| CHEMBL3810231 | — | — | 1 | - |
| CHEMBL3810027 | — | — | 1 | - |
| CHEMBL3809099 | — | — | 1 | - |
| CHEMBL3810258 | — | — | 1 | - |
| CHEMBL3808516 | — | — | 1 | - |
| CHEMBL3808663 | — | — | 1 | - |
| CHEMBL3809760 | — | — | 1 | - |
| CHEMBL3810057 | — | — | 1 | - |
| CHEMBL3809154 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3809863 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3810167 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3809120 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3809156 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3808627 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3809958 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3809328 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL118 | CELECOXIB | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3809116 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3810371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3809842 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3809922 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3809163 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3808774 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3810231 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3810027 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3809099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3810258 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3808516 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3808663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3809760 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3810057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3809154 | — | IC50 | > | 10000.0 | nM | - |