Assay Detail
Binding
CHEMBL3812007
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Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective Agonists of δ Opioid Receptor by Revisiting the "Message-Address" Concept.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 3 | - | - |
| EC50 | 3 | 6.71 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 2 | 7.52 |
| CHEMBL1400 | O-DESMETHYL TRAMADOL | — | 2 | 6.62 |
| CHEMBL1066 | (R,R)-TRAMADOL | — | 2 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1400 | O-DESMETHYL TRAMADOL | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1066 | (R,R)-TRAMADOL | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL38874 | DAMGO | Emax | = | 225.0 | % | - |
| CHEMBL1400 | O-DESMETHYL TRAMADOL | Emax | = | 220.0 | % | - |
| CHEMBL1066 | (R,R)-TRAMADOL | Emax | = | 220.0 | % | - |