Assay Detail
Functional
CHEMBL3812815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Respiratory syncytial virus A2 infected in Vero 76 cells after 5 days by crystal violet staining based plaque reduction assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Respiratory syncytial virus |
| Cell Type | Vero 76 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Respiratory syncytial virus (CHEMBL612679) ↗| Type | ORGANISM |
| Organism | Respiratory syncytial virus |
Publication
A combined in silico/in vitro approach unveils common molecular requirements for efficient BVDV RdRp binding of linear aromatic N-polycyclic systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.22 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564201 | 6-AZAURIDINE | — | 1 | 5.92 |
| CHEMBL3810277 | — | — | 1 | 5.00 |
| CHEMBL3808435 | — | — | 1 | 4.75 |
| CHEMBL3808848 | — | — | 1 | - |
| CHEMBL3809539 | — | — | 1 | - |
| CHEMBL3809779 | — | — | 1 | - |
| CHEMBL3810410 | — | — | 1 | - |
| CHEMBL3809002 | — | — | 1 | - |
| CHEMBL3809182 | — | — | 1 | - |
| CHEMBL3809700 | — | — | 1 | - |
| CHEMBL3810340 | — | — | 1 | - |
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | — | 1 | - |
| CHEMBL438605 | — | — | 1 | - |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | — | 1 | - |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564201 | 6-AZAURIDINE | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3810277 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3808435 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3808848 | — | EC50 | > | 16000.0 | nM | - |
| CHEMBL3809539 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3809779 | — | EC50 | > | 45000.0 | nM | - |
| CHEMBL3810410 | — | EC50 | > | 58000.0 | nM | - |
| CHEMBL3809002 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3809182 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3809700 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3810340 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | EC50 | - | — | - | |
| CHEMBL438605 | — | EC50 | - | — | - | |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | EC50 | - | — | - | |
| CHEMBL866 | MYCOPHENOLIC ACID | EC50 | - | — | - | |
| CHEMBL184 | ACYCLOVIR | EC50 | - | — | - |