Assay Detail
Binding
CHEMBL3820065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Citalopram from human recombinant SERT incubated for 1.5 hrs by microbeta scintillation counting method
16
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.97 | 8.33 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818478 | — | — | 2 | 8.33 |
| CHEMBL3818881 | — | — | 2 | 8.33 |
| CHEMBL3818805 | — | — | 2 | 7.60 |
| CHEMBL3819434 | — | — | 2 | 6.75 |
| CHEMBL2037526 | — | — | 2 | 6.55 |
| CHEMBL3819153 | — | — | 2 | 6.41 |
| CHEMBL3818124 | — | — | 2 | 5.51 |
| CHEMBL3819567 | — | — | 1 | - |
| CHEMBL3818935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818478 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL3818881 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL3818478 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3818805 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3818805 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3818881 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL3819434 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3819434 | — | Ki | = | 181.97 | nM | 6.74 |
| CHEMBL2037526 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL2037526 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL3819153 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL3819153 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL3818124 | — | Ki | = | 3056.0 | nM | 5.51 |
| CHEMBL3818124 | — | Ki | = | 3090.3 | nM | 5.51 |
| CHEMBL3819567 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3818935 | — | Inhibition | < | 50.0 | % | - |