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Assay Detail

CHEMBL3820152

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Trypanocidal activity against bloodstream form of Trypanosoma brucei 427 assessed as reduction in parasitic growth after 48 hrs by Alamar blue assay
34
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

New hydrazones of 5-nitro-2-furaldehyde with adamantanealkanohydrazides: synthesis and in vitro trypanocidal activity
Foscolos A, Papanastasiou I, Foscolos GB, Tsotinis A, Kellici TF, Mavromoustakos T, Taylor MC, Kelly JM
Medchemcomm (2016) 7 : 1229 -1236
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.69 7.12
IC90 17 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3819375 2 7.12
CHEMBL3818078 2 7.05
CHEMBL3818569 2 6.91
CHEMBL3819053 2 6.90
CHEMBL3818147 2 6.80
CHEMBL3818375 2 6.67
CHEMBL3819334 2 6.66
CHEMBL3818897 2 6.65
CHEMBL3817917 2 6.64
CHEMBL3197634 2 6.62
CHEMBL3819335 2 6.61
CHEMBL3818769 2 6.51
CHEMBL3819167 2 6.41
CHEMBL3818219 2 6.07
CHEMBL3212967 2 -
CHEMBL3818096 2 -
CHEMBL3818188 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3819375 IC50 = 75.0 nM 7.12
CHEMBL3818078 IC50 = 90.0 nM 7.05
CHEMBL3818569 IC50 = 122.0 nM 6.91
CHEMBL3819053 IC50 = 126.0 nM 6.90
CHEMBL3818147 IC50 = 158.0 nM 6.80
CHEMBL3818375 IC50 = 216.0 nM 6.67
CHEMBL3819334 IC50 = 221.0 nM 6.66
CHEMBL3818897 IC50 = 223.0 nM 6.65
CHEMBL3817917 IC50 = 231.0 nM 6.64
CHEMBL3197634 IC50 = 242.0 nM 6.62
CHEMBL3819335 IC50 = 244.0 nM 6.61
CHEMBL3818769 IC50 = 306.0 nM 6.51
CHEMBL3819167 IC50 = 386.0 nM 6.41
CHEMBL3818219 IC50 = 851.0 nM 6.07
CHEMBL3212967 IC50 > 35000.0 nM -
CHEMBL3818096 IC50 > 35000.0 nM -
CHEMBL3818188 IC50 > 30000.0 nM -
CHEMBL3818219 IC90 = 1040.0 nM -
CHEMBL3197634 IC90 = 553.0 nM -
CHEMBL3819167 IC90 = 560.0 nM -
CHEMBL3817917 IC90 = 599.0 nM -
CHEMBL3819053 IC90 = 207.0 nM -
CHEMBL3818569 IC90 = 177.0 nM -
CHEMBL3818375 IC90 = 425.0 nM -
CHEMBL3818769 IC90 = 459.0 nM -
CHEMBL3818147 IC90 = 322.0 nM -
CHEMBL3819335 IC90 = 406.0 nM -
CHEMBL3819334 IC90 = 573.0 nM -
CHEMBL3818078 IC90 = 167.0 nM -
CHEMBL3819375 IC90 = 98.0 nM -
CHEMBL3818897 IC90 = 643.0 nM -
CHEMBL3212967 IC90 > 35000.0 nM -
CHEMBL3818096 IC90 > 35000.0 nM -
CHEMBL3818188 IC90 > 30000.0 nM -