Assay Detail
Functional
CHEMBL3820723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against epimastigote stage of Trypanosoma cruzi Tulahuen CL98 after 48 hrs by hemocytometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.48 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1984208 | — | — | 1 | 6.16 |
| CHEMBL3818937 | — | — | 1 | 5.65 |
| CHEMBL404939 | — | — | 1 | 5.56 |
| CHEMBL3819063 | — | — | 1 | 5.32 |
| CHEMBL3819401 | — | — | 1 | 5.21 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1984208 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3818937 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL404939 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL3819063 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL3819401 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 10670.0 | nM | 4.97 |