Assay Detail
Functional
CHEMBL3821538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relaxant activity in potassium depolarized guinea pig ileum longitudinal smooth muscle assessed as inhibition of calcium-induced contraction after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.58 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818643 | — | — | 1 | 7.77 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.96 |
| CHEMBL3818880 | — | — | 1 | 5.45 |
| CHEMBL3817876 | — | — | 1 | 5.32 |
| CHEMBL3819606 | — | — | 1 | 5.01 |
| CHEMBL3819349 | — | — | 1 | 4.99 |
| CHEMBL3819185 | — | — | 1 | 4.93 |
| CHEMBL3817893 | — | — | 1 | 4.91 |
| CHEMBL3817895 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818643 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3818880 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL3817876 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL3819606 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL3819349 | — | IC50 | = | 10270.0 | nM | 4.99 |
| CHEMBL3819185 | — | IC50 | = | 11620.0 | nM | 4.93 |
| CHEMBL3817893 | — | IC50 | = | 12420.0 | nM | 4.91 |
| CHEMBL3817895 | — | IC50 | = | 14490.0 | nM | 4.84 |