Assay Detail
ADMET
CHEMBL3821695
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Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.04 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1109 | SULFAPHENAZOLE | 4.0 | 1 | 6.13 |
| CHEMBL3408523 | — | — | 1 | 5.18 |
| CHEMBL3818560 | — | — | 1 | 4.93 |
| CHEMBL3818643 | — | — | 1 | 4.87 |
| CHEMBL3819606 | — | — | 1 | 4.74 |
| CHEMBL211204 | — | — | 1 | 4.74 |
| CHEMBL3819226 | — | — | 1 | 4.72 |
| CHEMBL3819185 | — | — | 1 | - |
| CHEMBL3819349 | — | — | 1 | - |
| CHEMBL3408526 | — | — | 1 | - |
| CHEMBL3408529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1109 | SULFAPHENAZOLE | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3408523 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3818560 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL3818643 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3819606 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL211204 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL3819226 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3819185 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3819349 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3408526 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3408529 | — | IC50 | > | 20000.0 | nM | - |