Assay Detail
ADMET
CHEMBL3825882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CYP2C9 by P450-Glo luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.17 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822867 | — | — | 1 | 5.38 |
| CHEMBL3822473 | — | — | 1 | 5.30 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 5.04 |
| CHEMBL3823873 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822867 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL3822473 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 9210.0 | nM | 5.04 |
| CHEMBL3823873 | — | IC50 | = | 10990.0 | nM | 4.96 |