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Assay Detail

CHEMBL3832787

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Functional
AntiTrypanosoma brucei activity T. b. rhodesiense IC50 (uM)
ChEMBL ↗
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849) ↗
Type ORGANISM
Organism Trypanosoma brucei

Publication

MMV Pathogen Box Bioactivity Data
Nathan group, Weill Cornell Medical College; Barry Lab, NIAID NIH; Winzeler lab, UCSD; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Univ. of Antwerp; London School of Hygiene and Tropical Medicine; Parasite Chemotherapy Unit at Swiss Tropical and Public Health Institute; Huston group at the University of Vermont; Castellanos group at UTMB, Galveston, Texas; Sakanari Lab, Univ. of Calif. San Francisco; Townson (Simon) Lab, Imperial College London; Fidelis Cho-Ngwa Lab, University of Buea, Buea, Cameroon; Laboratory of Molecular Parasitology at the New York Blood Center; Bickle Lab, London School of Hygiene and Tropical Medicine; Keiser Lab, Swiss Tropical and Public Health Institute; Caffrey group at the Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; University of Cape Town; Shanmugam group at CSIR-National Chemical Laboratory, Pune (India); Novartis Institute for Tropical Disease-Singapore; Abbvie

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 5.76 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3431330 — — 1 6.96
CHEMBL3546548 — — 1 6.92
CHEMBL3431272 — — 1 6.89
CHEMBL3431084 — — 1 6.85
CHEMBL1872842 — — 1 6.80
CHEMBL413331 — — 1 6.70
CHEMBL45843 — — 1 6.64
CHEMBL2441383 — — 1 6.64
CHEMBL393580 — — 1 6.62
CHEMBL402548 DANUSERTIB 2.0 1 6.43
CHEMBL3431063 — — 1 6.42
CHEMBL3431007 — — 1 6.40
CHEMBL3546405 — — 1 6.40
CHEMBL1836611 — — 1 6.37
CHEMBL3431223 — — 1 6.34
CHEMBL1308225 — — 1 6.32
CHEMBL3431099 — — 1 6.19
CHEMBL520654 — — 1 6.11
CHEMBL3637895 — — 1 6.02
CHEMBL238442 — — 1 6.01
CHEMBL41 FLUOXETINE 4.0 1 5.99
CHEMBL227240 — — 1 5.97
CHEMBL241634 — — 1 5.89
CHEMBL3431166 — — 1 5.88
CHEMBL1197423 — — 1 5.79
CHEMBL3431105 — — 1 5.77
CHEMBL1515447 HOMOCHLORCYCLIZINE 2.0 1 5.71
CHEMBL394241 — — 1 5.57
CHEMBL227667 — — 1 5.52
CHEMBL1836562 — — 1 5.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3431330 — IC50 = 110.0 nM 6.96
CHEMBL3546548 — IC50 = 120.0 nM 6.92
CHEMBL3431272 — IC50 = 130.0 nM 6.89
CHEMBL3431084 — IC50 = 140.0 nM 6.85
CHEMBL1872842 — IC50 = 160.0 nM 6.80
CHEMBL413331 — IC50 = 200.0 nM 6.70
CHEMBL45843 — IC50 = 230.0 nM 6.64
CHEMBL2441383 — IC50 = 230.0 nM 6.64
CHEMBL393580 — IC50 = 240.0 nM 6.62
CHEMBL402548 DANUSERTIB IC50 = 370.0 nM 6.43
CHEMBL3431063 — IC50 = 380.0 nM 6.42
CHEMBL3431007 — IC50 = 400.0 nM 6.40
CHEMBL3546405 — IC50 = 400.0 nM 6.40
CHEMBL1836611 — IC50 = 430.0 nM 6.37
CHEMBL3431223 — IC50 = 460.0 nM 6.34
CHEMBL1308225 — IC50 = 480.0 nM 6.32
CHEMBL3431099 — IC50 = 650.0 nM 6.19
CHEMBL520654 — IC50 = 780.0 nM 6.11
CHEMBL3637895 — IC50 = 960.0 nM 6.02
CHEMBL238442 — IC50 = 970.0 nM 6.01
CHEMBL41 FLUOXETINE IC50 = 1020.0 nM 5.99
CHEMBL227240 — IC50 = 1080.0 nM 5.97
CHEMBL241634 — IC50 = 1290.0 nM 5.89
CHEMBL3431166 — IC50 = 1310.0 nM 5.88
CHEMBL1197423 — IC50 = 1630.0 nM 5.79
CHEMBL3431105 — IC50 = 1700.0 nM 5.77
CHEMBL1515447 HOMOCHLORCYCLIZINE IC50 = 1940.0 nM 5.71
CHEMBL394241 — IC50 = 2700.0 nM 5.57
CHEMBL227667 — IC50 = 3000.0 nM 5.52
CHEMBL1836562 — IC50 = 3110.0 nM 5.51
CHEMBL3637894 — IC50 = 3070.0 nM 5.51
CHEMBL1197424 — IC50 = 3720.0 nM 5.43
CHEMBL1198787 — IC50 = 3810.0 nM 5.42
CHEMBL241427 — IC50 = 3770.0 nM 5.42
CHEMBL3637897 — IC50 = 4000.0 nM 5.40
CHEMBL2171461 — IC50 = 4120.0 nM 5.38
CHEMBL394474 — IC50 = 5260.0 nM 5.28
CHEMBL474899 — IC50 = 5620.0 nM 5.25
CHEMBL472881 — IC50 = 11780.0 nM 4.93
CHEMBL3637893 — IC50 = 13110.0 nM 4.88
CHEMBL1094051 — IC50 = 16380.0 nM 4.79
CHEMBL2229099 TOLFENPYRAD IC50 = 20360.0 nM 4.69
CHEMBL1683021 — IC50 = 22870.0 nM 4.64
CHEMBL3431191 — IC50 = 25100.0 nM 4.60
CHEMBL466426 DIFENOCONAZOLE IC50 = 26230.0 nM 4.58
CHEMBL3637899 — IC50 = 26160.0 nM 4.58
CHEMBL511692 — IC50 = 27180.0 nM 4.57
CHEMBL1566634 BITERTANOL IC50 = 28020.0 nM 4.55
CHEMBL3546668 — IC50 = 30100.0 nM 4.52
CHEMBL3115821 — IC50 < 130.0 nM -