Assay Detail
Binding
CHEMBL3853647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at SERT in rat synaptosomes obtained from whole brain minus striatum and cerebellum assessed as release of [3H]5-HT by liquid scintillation counting method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.66 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471839 | — | — | 1 | 8.47 |
| CHEMBL3921422 | — | — | 1 | 7.40 |
| CHEMBL3982376 | — | — | 1 | 7.27 |
| CHEMBL3913053 | — | — | 1 | 6.96 |
| CHEMBL3912463 | — | — | 1 | 6.54 |
| CHEMBL3945529 | — | — | 1 | 6.42 |
| CHEMBL3930376 | — | — | 1 | 6.19 |
| CHEMBL3963971 | — | — | 1 | 6.18 |
| CHEMBL3974905 | — | — | 1 | 6.12 |
| CHEMBL3896023 | — | — | 1 | 5.94 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 5.75 |
| CHEMBL3933915 | — | — | 1 | - |
| CHEMBL3965276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471839 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3921422 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3982376 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3913053 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3912463 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL3945529 | — | EC50 | = | 384.0 | nM | 6.42 |
| CHEMBL3930376 | — | EC50 | = | 646.0 | nM | 6.19 |
| CHEMBL3963971 | — | EC50 | = | 663.0 | nM | 6.18 |
| CHEMBL3974905 | — | EC50 | = | 756.0 | nM | 6.12 |
| CHEMBL3896023 | — | EC50 | = | 1156.0 | nM | 5.94 |
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3933915 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3965276 | — | EC50 | > | 10000.0 | nM | - |