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Assay Detail

CHEMBL3854071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Influenza A virus A/PR/8/34 (H1N1) infected in MDCK cells assessed as reduction in plaque formation after 2 days by plaque reduction assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Cell Type MDCK
Confidence 1 — Organism
Curated By Autocuration

Publication

Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics.
Massari S, Goracci L, Desantis J, Tabarrini O.
J Med Chem (2016) 59 : 7699 -7718
PubMed 27046062 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 4.72 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3577824 1 6.00
CHEMBL3947563 1 5.00
CHEMBL3288047 1 4.73
CHEMBL284733 DICLAZURIL 2.0 1 4.51
CHEMBL388590 BENZBROMARONE 4.0 1 4.41
CHEMBL1698011 TRENBOLONE ACETATE 2.0 1 4.29
CHEMBL3288048 1 4.12
CHEMBL3945111 1 -
CHEMBL3577796 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3577824 EC50 = 1000.0 nM 6.00
CHEMBL3947563 EC50 = 10000.0 nM 5.00
CHEMBL3288047 EC50 = 18600.0 nM 4.73
CHEMBL284733 DICLAZURIL EC50 = 31000.0 nM 4.51
CHEMBL388590 BENZBROMARONE EC50 = 39000.0 nM 4.41
CHEMBL1698011 TRENBOLONE ACETATE EC50 = 51000.0 nM 4.29
CHEMBL3288048 EC50 = 75000.0 nM 4.12
CHEMBL3945111 EC50 > 100000.0 nM -
CHEMBL3577796 EC50 > 100000.0 nM -