Assay Detail
Binding
CHEMBL3855331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of T-type calcium channel Cav3.1 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent T-type calcium channel subunit alpha-1G (CHEMBL4641) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.96 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1684950 | SUVECALTAMIDE | 2.0 | 1 | 8.92 |
| CHEMBL3892579 | — | — | 1 | 7.54 |
| CHEMBL3934636 | ULIXACALTAMIDE | 1.0 | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1684950 | SUVECALTAMIDE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3892579 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3934636 | ULIXACALTAMIDE | IC50 | = | 37.0 | nM | 7.43 |