Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3934636

ULIXACALTAMIDE
Phase I
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Phase I
CC(C)(C)NC(=O)CN1CCC(CNC(=O)c2cc(F)cc(Cl)c2)CC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL3934636
Name ULIXACALTAMIDE
Phase Phase I
Structure Type MOL
InChI Key JOCLITFYIMJMNK-UHFFFAOYSA-N

Known Names

NP-169944 NP169944 PRAX-944 PRAX944 Ulixacaltamide Z-944 Z944
3
Targets
9
Activities
1
Assay Types
0
PK Parameters
10
Publications
7
Known Names
1
Indications

Molecular Properties

383.9
MW (Da)
2.84
ALogP
3
HBA
2
HBD
61.4
PSA (Ų)
0.82
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral
USAN Year 2023

Extended Properties

Molecular Formula C19H27ClFN3O2
MW 383.89
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness -1.97

Indications

Essential Tremor

Activity Summary

IC50 9 meas. best 7.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Voltage-dependent T-type calcium channel subunit alpha-1G
CHEMBL4641
 IC50 7.43 7.43 37.0 3
Voltage-dependent T-type calcium channel subunit alpha-1H
CHEMBL1859
 IC50 7.14 7.14 73.0 3
Voltage-dependent T-type calcium channel subunit alpha-1I
CHEMBL5558
 IC50 7.07 7.07 86.0 3

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Voltage-dependent T-type calcium channel subunit alpha-1G IC50 = 37.0 nM 7.43 Inhibition of T-type calcium channel Cav3.1 (unknown origin) expressed in HEK293... 27579577
Voltage-dependent T-type calcium channel subunit alpha-1G IC50 = 37.0 nM 7.43 Inhibition of human CaV 3.1 by manual patch clamp assay 27933950
Voltage-dependent T-type calcium channel subunit alpha-1G IC50 = 37.0 nM 7.43 Inhibition of Cav3.1 (unknown origin) 37012671
Voltage-dependent T-type calcium channel subunit alpha-1H IC50 = 73.0 nM 7.14 Inhibition of recombinant T-type calcium channel Cav3.2 (unknown origin) express... 27579577
Voltage-dependent T-type calcium channel subunit alpha-1H IC50 = 73.0 nM 7.14 Inhibition of human CaV 3.2 by manual patch clamp assay 27933950
Voltage-dependent T-type calcium channel subunit alpha-1H IC50 = 73.0 nM 7.14 Inhibition of Cav3.2 (unknown origin) 37012671
Voltage-dependent T-type calcium channel subunit alpha-1I IC50 = 86.0 nM 7.07 Inhibition of T-type calcium channel Cav3.3 (unknown origin) expressed in HEK293... 27579577
Voltage-dependent T-type calcium channel subunit alpha-1I IC50 = 86.0 nM 7.07 Inhibition of human CaV 3.3 by manual patch clamp assay 27933950
Voltage-dependent T-type calcium channel subunit alpha-1I IC50 = 86.0 nM 7.07 Inhibition of Cav3.3 (unknown origin) 37012671

Literature References

PubMed DOI Target Context # Activities
27579577 10.1021/acs.jmedchem.6b00756 Voltage-dependent T-type calcium channel subunit alpha-1I 1
27579577 10.1021/acs.jmedchem.6b00756 Voltage-dependent T-type calcium channel subunit alpha-1H 1
27579577 10.1021/acs.jmedchem.6b00756 Voltage-dependent T-type calcium channel subunit alpha-1G 1
27933950 10.1021/acs.jmedchem.6b01356 Voltage-dependent T-type calcium channel subunit alpha-1G 1
27933950 10.1021/acs.jmedchem.6b01356 Voltage-dependent T-type calcium channel subunit alpha-1H 1
27933950 10.1021/acs.jmedchem.6b01356 Voltage-dependent T-type calcium channel subunit alpha-1I 1
37012671 10.1021/acs.jmedchem.2c01975 Voltage-dependent T-type calcium channel subunit alpha-1G 1
37012671 10.1021/acs.jmedchem.2c01975 Voltage-dependent T-type calcium channel subunit alpha-1H 1
37012671 10.1021/acs.jmedchem.2c01975 Voltage-dependent T-type calcium channel subunit alpha-1I 1
37012671 10.1021/acs.jmedchem.2c01975 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine