Assay Detail
ADMET
CHEMBL3855412
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Inhibition of CYP2D6 (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.82 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3914727 | — | — | 1 | 5.27 |
| CHEMBL3978980 | — | — | 1 | 5.11 |
| CHEMBL3940521 | — | — | 1 | 5.11 |
| CHEMBL3972392 | — | — | 1 | 4.90 |
| CHEMBL3985591 | — | — | 1 | 4.80 |
| CHEMBL3933543 | — | — | 1 | 4.68 |
| CHEMBL3956923 | — | — | 1 | 4.62 |
| CHEMBL3959681 | — | — | 1 | 4.59 |
| CHEMBL3976470 | — | — | 1 | 4.59 |
| CHEMBL3905741 | — | — | 1 | 4.57 |
| CHEMBL3814206 | — | — | 1 | - |
| CHEMBL3960195 | — | — | 1 | - |
| CHEMBL3913348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3914727 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL3978980 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL3940521 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3972392 | — | IC50 | = | 12710.0 | nM | 4.90 |
| CHEMBL3985591 | — | IC50 | = | 15750.0 | nM | 4.80 |
| CHEMBL3933543 | — | IC50 | = | 20950.0 | nM | 4.68 |
| CHEMBL3956923 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL3959681 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL3976470 | — | IC50 | = | 25650.0 | nM | 4.59 |
| CHEMBL3905741 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3814206 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3960195 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3913348 | — | IC50 | > | 30000.0 | nM | - |