Assay Detail
Binding
CHEMBL3856466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1/cyclin B (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.73 | 9.00 |
| Ki | 1 | 5.79 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3897452 | — | — | 1 | 9.00 |
| CHEMBL3545083 | RGB-286638 | 1.0 | 1 | 8.70 |
| CHEMBL3905910 | VORUCICLIB | 2.0 | 1 | 7.60 |
| CHEMBL3969723 | — | — | 1 | 7.10 |
| CHEMBL3655762 | CYC-065 | 2.0 | 1 | 6.24 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3897452 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3545083 | RGB-286638 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3905910 | VORUCICLIB | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3969723 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3655762 | CYC-065 | IC50 | = | 578.0 | nM | 6.24 |
| CHEMBL3301610 | ABEMACICLIB | Ki | = | 1627.0 | nM | 5.79 |