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Compound Detail

CHEMBL3897452

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CCNCc1cncc(-c2cccc3[nH]nc(-c4nc5c(F)cc(F)cc5[nH]4)c23)c1C

Basic Information

ChEMBL ID CHEMBL3897452
Phase Preclinical
Structure Type MOL
InChI Key VWQIQPRBMMSYCE-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

418.4
MW (Da)
4.86
ALogP
4
HBA
3
HBD
82.3
PSA (Ų)
0.38
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H20F2N6
MW 418.45
Aromatic Rings 5
Heavy Atoms 31
NP-Likeness -0.98

Activity Summary

IC50 3 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cyclin-dependent kinase 1/cyclin B1
CHEMBL1907602
IC50 9.0 9.0 1.0 1
CDK2/Cyclin A2
CHEMBL3038469
IC50 9.0 9.0 1.0 1
Cyclin-dependent kinase 4/G1/S-specific cyclin-E1
CHEMBL3885554
IC50 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
27171036 10.1021/acs.jmedchem.6b00150 Cyclin-dependent kinase 4/G1/S-specific cyclin-E1 1
27171036 10.1021/acs.jmedchem.6b00150 CDK2/Cyclin A2 1
27171036 10.1021/acs.jmedchem.6b00150 Cyclin-dependent kinase 1/cyclin B1 1

Data from ChEMBL 36 via Core Engine