Assay Detail
Binding
CHEMBL3856506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using pRB (773 to 928 residues) as substrate after 30 mins by [gamma-33P]ATP based scintillation counting analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.94 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270687 | MERIOLIN 5 | — | 1 | 8.22 |
| CHEMBL270686 | MERIOLIN 3 | — | 1 | 8.22 |
| CHEMBL270897 | MERIOLIN 2 | — | 1 | 7.75 |
| CHEMBL405665 | MERIOLIN 1 | — | 1 | 7.58 |
| CHEMBL270346 | MERIOLIN 9 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270687 | MERIOLIN 5 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL270686 | MERIOLIN 3 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL270897 | MERIOLIN 2 | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL405665 | MERIOLIN 1 | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL270346 | MERIOLIN 9 | IC50 | > | 10000.0 | nM | - |