Assay Detail
Functional
CHEMBL3856716
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Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.22 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3960277 | — | — | 1 | 5.89 |
| CHEMBL3968515 | — | — | 1 | 5.57 |
| CHEMBL3900190 | — | — | 1 | 5.46 |
| CHEMBL3917110 | — | — | 1 | 5.41 |
| CHEMBL3905090 | — | — | 1 | 5.31 |
| CHEMBL201761 | SALINAZID | 2.0 | 1 | 5.24 |
| CHEMBL3908133 | — | — | 1 | 5.19 |
| CHEMBL3936088 | — | — | 1 | 5.12 |
| CHEMBL3983900 | — | — | 1 | 5.04 |
| CHEMBL3945027 | — | — | 1 | 4.65 |
| CHEMBL3914087 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3960277 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3968515 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3900190 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3917110 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3905090 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL201761 | SALINAZID | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3908133 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3936088 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3983900 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3945027 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL3914087 | — | IC50 | = | 27000.0 | nM | 4.57 |