Compound Detail

CHEMBL201761

SALINAZID

🧪 Phase II

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🧪 Phase II

O=C(N/N=C/c1ccccc1O)c1ccncc1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL201761
Name	SALINAZID
Phase	Phase II
Structure Type	MOL
InChI Key	VBIZUNYMJSPHBH-OQLLNIDSSA-N

Known Names

N'-(2-hydroxybenzylidene)isonicotinohydrazide NSC-33760 Salinazid Salinazide

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

241.2

MW (Da)

1.55

ALogP

HBA

HBD

74.6

PSA (Å²)

0.63

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Achiral

USAN Stem

sal-

Extended Properties

Molecular Formula	C13H11N3O2
MW	241.25
Aromatic Rings	2
Heavy Atoms	18
NP-Likeness	-1.54

Activity Summary

IC50 7 meas. best 5.38

EC50 2 meas. best 4.82

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Entamoeba histolytica CHEMBL612853	IC50	5.38	5.38	4140.0	1
NON-PROTEIN TARGET CHEMBL3879801	IC50	5.24	5.075	5700.0	2
Unchecked CHEMBL612545	EC50	4.82	4.82	15170.0	1
H9c2 CHEMBL614576	EC50	4.74	4.74	18200.0	1
Unchecked CHEMBL612545	IC50	4.69	4.5833	20520.0	3
Rattus norvegicus CHEMBL376	IC50	4.54	4.54	28900.0	1

Pharmacokinetic Data

Parameter	Value	Units	Species
T1/2	2.7	hr	-

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Entamoeba histolytica	IC50	=	4140.0	nM	5.38	Antiameobic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs using ...	22309914
NON-PROTEIN TARGET	IC50	=	5700.0	nM	5.24	Cytotoxicity against human HL60 cells assessed as decrease in cell viability aft...	27187862
NON-PROTEIN TARGET	IC50	=	12400.0	nM	4.91	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability aft...	27187862
Unchecked	EC50	=	15170.0	nM	4.82	PUBCHEM_BIOASSAY: A cytotoxicity screen of small molecule inhibitors of the PhoP...	-
H9c2	EC50	=	18200.0	nM	4.74	Protection against t-BHP-induced oxidative injury in rat H9c2 cells assessed as ...	27187862
Unchecked	IC50	=	20520.0	nM	4.69	PUBCHEM_BIOASSAY: A counter screen for small molecule screen for inhibitors of t...	-
Unchecked	IC50	=	24688.0	nM	4.61	PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi...	-
Rattus norvegicus	IC50	=	28900.0	nM	4.54	Cytotoxicity against rat H9c2 cells assessed as decrease in cell viability after...	27187862
Unchecked	IC50	=	35920.0	nM	4.45	PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in S...	-

Literature References

PubMed	DOI	Target Context	# Activities
28734582	10.1016/j.bmcl.2017.07.019	No relevant target	7
27187862	10.1016/j.ejmech.2016.05.015	H9c2	3
24924425	10.1016/j.bmc.2014.05.034	No relevant target	3
27187862	10.1016/j.ejmech.2016.05.015	NON-PROTEIN TARGET	2
28734582	10.1016/j.bmcl.2017.07.019	ARPE-19	2
27187862	10.1016/j.ejmech.2016.05.015	MCF7	2
-	10.6019/CHEMBL4651402	SARS-CoV-2	2
36105345	10.1021/acsmedchemlett.2c00250	A2780	2
30429096	10.1016/j.bmc.2018.11.004	No relevant target	2
-	10.6019/CHEMBL4495565	SARS-CoV-2	2
24924425	10.1016/j.bmc.2014.05.034	NON-PROTEIN TARGET	2
-	10.1007/s00044-011-9662-9	Candida albicans	1
25982329	10.1016/j.ejmech.2015.04.042	Escherichia coli	1
-	10.1007/s00044-011-9662-9	Escherichia coli	1
-	10.1007/s00044-011-9662-9	Mycobacterium tuberculosis	1
-	10.1007/s00044-011-9662-9	Human immunodeficiency virus 1	1
-	10.1007/s00044-011-9662-9	MT4	1
-	10.1007/s00044-011-9662-9	Bacillus subtilis	1
-	10.6019/EOS300108	HepG2	1
22309914	10.1016/j.ejmech.2012.01.030	MCF7	1

Data from ChEMBL 36 via Core Engine