Assay Detail
Functional
CHEMBL3856719
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Protection against t-BHP-induced oxidative injury in rat H9c2 cells assessed as increase in cell viability incubated for 10 mins followed by stimulation with t-BHP for 24 hrs by neutral red staining based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | H9c2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.81 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2261891 | — | — | 1 | 4.94 |
| CHEMBL3975887 | — | — | 1 | 4.75 |
| CHEMBL201761 | SALINAZID | 2.0 | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2261891 | — | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3975887 | — | EC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL201761 | SALINAZID | EC50 | = | 18200.0 | nM | 4.74 |