Assay Detail
Binding
CHEMBL3857932
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Displacement of [3H]LTD4 from LTD4 receptor in guinea pig lung membrane
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.91 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 9.30 |
| CHEMBL280481 | VERLUKAST | 2.0 | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL787 | MONTELUKAST | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL280481 | VERLUKAST | IC50 | = | 3.1 | nM | 8.51 |