Assay Detail
Functional
CHEMBL3859955
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Antiviral activity against HIV1 3B infected in human MT2 cells assessed as protection against virus-induced cytopathic effect after 5 days by XTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.80 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | 4.0 | 1 | 8.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 5000.0 | nM | 5.30 |