Assay Detail
Functional
CHEMBL3860281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Y infected in human U2OS cells after 96 hrs by Draq5 staining-based high content screening assay
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.14 | 6.47 |
| Emax | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | 4.0 | 2 | 6.47 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 2 | 5.40 |
| CHEMBL3410627 | — | — | 2 | 5.26 |
| CHEMBL3961604 | — | — | 2 | 4.81 |
| CHEMBL3936285 | — | — | 2 | 4.67 |
| CHEMBL3927334 | — | — | 2 | 4.20 |
| CHEMBL2063495 | — | — | 2 | - |
| CHEMBL3908348 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL3410627 | — | EC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL3961604 | — | EC50 | = | 15370.0 | nM | 4.81 |
| CHEMBL3936285 | — | EC50 | = | 21570.0 | nM | 4.67 |
| CHEMBL3927334 | — | EC50 | = | 63100.0 | nM | 4.20 |
| CHEMBL2063495 | — | EC50 | = | 144000.0 | nM | - |
| CHEMBL3908348 | — | EC50 | = | 101300.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | Emax | = | 103.5 | % | - |
| CHEMBL290960 | NIFURTIMOX | Emax | = | 101.5 | % | - |
| CHEMBL3410627 | — | Emax | = | 86.99 | % | - |
| CHEMBL3908348 | — | Emax | = | 95.23 | % | - |
| CHEMBL3936285 | — | Emax | = | 92.75 | % | - |
| CHEMBL2063495 | — | Emax | = | 68.7 | % | - |
| CHEMBL3927334 | — | Emax | = | 96.6 | % | - |
| CHEMBL3961604 | — | Emax | = | 95.22 | % | - |