Assay Detail
Binding
CHEMBL3861570
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]clonidine from alpha2 adrenergic receptor in rat brain cerebral cortex after 25 mins by microbeta scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.66 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 8.57 |
| CHEMBL3949348 | — | — | 1 | 6.54 |
| CHEMBL3958008 | — | — | 1 | 6.43 |
| CHEMBL3979966 | — | — | 1 | 6.30 |
| CHEMBL3921558 | — | — | 1 | 6.09 |
| CHEMBL3971078 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134 | CLONIDINE | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL3949348 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL3958008 | — | Ki | = | 370.5 | nM | 6.43 |
| CHEMBL3979966 | — | Ki | = | 505.7 | nM | 6.30 |
| CHEMBL3921558 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL3971078 | — | Ki | = | 893.0 | nM | 6.05 |