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Assay Detail

CHEMBL3862619

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TNFalpha-induced NFkappaB activation in mouse NIH-3T3 cells expressing NFkappaB (unknown origin) preincubated for 15 mins followed by TNFalpha addition measured after 6 hrs by luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type NIH3T3
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.
Pollastro F, Golin S, Chianese G, Putra MY, Schiano Moriello A, De Petrocellis L, García V, Munoz E, Taglialatela-Scafati O, Appendino G.
J Nat Prod (2016) 79 : 1762 -1768
PubMed 27352042 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.73 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL193093 1 5.10
CHEMBL3890789 1 4.65
CHEMBL3899770 1 4.45
CHEMBL497044 INCENSOLE 1 -
CHEMBL3979367 1 -
CHEMBL3959869 1 -
CHEMBL3948101 1 -
CHEMBL3943485 1 -
CHEMBL3904515 1 -
CHEMBL3975348 1 -
CHEMBL3913521 1 -
CHEMBL3983336 1 -
CHEMBL3922508 1 -
CHEMBL3894504 1 -
CHEMBL3931428 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL193093 IC50 = 7900.0 nM 5.10
CHEMBL3890789 IC50 = 22400.0 nM 4.65
CHEMBL3899770 IC50 = 35500.0 nM 4.45
CHEMBL497044 INCENSOLE IC50 > 50000.0 nM -
CHEMBL3979367 IC50 > 50000.0 nM -
CHEMBL3959869 IC50 > 50000.0 nM -
CHEMBL3948101 IC50 > 50000.0 nM -
CHEMBL3943485 IC50 > 50000.0 nM -
CHEMBL3904515 IC50 > 50000.0 nM -
CHEMBL3975348 IC50 > 50000.0 nM -
CHEMBL3913521 IC50 > 50000.0 nM -
CHEMBL3983336 IC50 > 50000.0 nM -
CHEMBL3922508 IC50 > 50000.0 nM -
CHEMBL3894504 IC50 > 50000.0 nM -
CHEMBL3931428 IC50 > 50000.0 nM -