Compound Detail
CHEMBL3890789
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C/C1=C\C[C@]2(C(C)C)CC[C@@](C)(O2)[C@@H](OC(=O)Cc2ccccc2)CC/C(C)=C/CC1
Basic Information
| ChEMBL ID | CHEMBL3890789 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QCWPMFRYVOOFJC-UKTRBUHOSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
424.6
MW (Da)
6.96
ALogP
3
HBA
0
HBD
35.5
PSA (Ų)
0.39
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.66
EC50 1 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Heat sensitive channel TRPV3 CHEMBL3879847 | EC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Heat sensitive channel TRPV3 CHEMBL3879847 | IC50 | 4.66 | 4.66 | 21700.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.65 | 4.65 | 22400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Heat sensitive channel TRPV3 | EC50 | = | 1200.0 | nM | 5.92 | Activation of rat TRPV3 overexpressed in HEK293 cells assessed as increase in 2-... | 27352042 |
| Heat sensitive channel TRPV3 | IC50 | = | 21700.0 | nM | 4.66 | Antagonist activity at rat TRPV3 overexpressed in HEK293 cells assessed as inhib... | 27352042 |
| Unchecked | IC50 | = | 22400.0 | nM | 4.65 | Inhibition of TNFalpha-induced NFkappaB activation in mouse NIH-3T3 cells expres... | 27352042 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27352042 | 10.1021/acs.jnatprod.6b00141 | Heat sensitive channel TRPV3 | 3 |
| 27352042 | 10.1021/acs.jnatprod.6b00141 | Unchecked | 1 |
| 27352042 | 10.1021/acs.jnatprod.6b00141 | Signal transducer and activator of transcription 3 | 1 |
Data from ChEMBL 36 via Core Engine