Assay Detail
Binding
CHEMBL3862618
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Antagonist activity at rat TRPV3 overexpressed in HEK293 cells assessed as inhibition of thymol-induced increase in intracellular Ca2+ levels preincubated for 5 mins prior to thymol-stimulation by Fluo-4AM dye-based spectrofluorometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Heat sensitive channel TRPV3 (CHEMBL3879847) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.04 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3943485 | — | — | 1 | 6.82 |
| CHEMBL497044 | INCENSOLE | — | 1 | 5.68 |
| CHEMBL3979367 | — | — | 1 | 5.66 |
| CHEMBL3983336 | — | — | 1 | 5.24 |
| CHEMBL3922508 | — | — | 1 | 4.91 |
| CHEMBL3975348 | — | — | 1 | 4.88 |
| CHEMBL3913521 | — | — | 1 | 4.68 |
| CHEMBL3890789 | — | — | 1 | 4.66 |
| CHEMBL3899770 | — | — | 1 | 4.62 |
| CHEMBL3894504 | — | — | 1 | 4.24 |
| CHEMBL3948101 | — | — | 1 | 4.03 |
| CHEMBL3959869 | — | — | 1 | - |
| CHEMBL3904515 | — | — | 1 | - |
| CHEMBL3931428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3943485 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL497044 | INCENSOLE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3979367 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3983336 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3922508 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL3975348 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3913521 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL3890789 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL3899770 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL3894504 | — | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL3948101 | — | IC50 | = | 94400.0 | nM | 4.03 |
| CHEMBL3959869 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3904515 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3931428 | — | IC50 | > | 100000.0 | nM | - |