Compound Detail
CHEMBL497044
INCENSOLE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL497044 |
| Name | INCENSOLE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SSBZLMMXFQMHDP-REDNKFHQSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
306.5
MW (Da)
5.17
ALogP
2
HBA
1
HBD
29.5
PSA (Ų)
0.68
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.68
EC50 1 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Heat sensitive channel TRPV3 CHEMBL3879847 | EC50 | 5.68 | 5.68 | 2100.0 | 1 |
| Heat sensitive channel TRPV3 CHEMBL3879847 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
| Signal transducer and activator of transcription 3 CHEMBL4026 | IC50 | 4.8 | 4.8 | 15840.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Heat sensitive channel TRPV3 | EC50 | = | 2100.0 | nM | 5.68 | Activation of rat TRPV3 overexpressed in HEK293 cells assessed as increase in 2-... | 27352042 |
| Heat sensitive channel TRPV3 | IC50 | = | 2100.0 | nM | 5.68 | Antagonist activity at rat TRPV3 overexpressed in HEK293 cells assessed as inhib... | 27352042 |
| Signal transducer and activator of transcription 3 | IC50 | = | 15840.0 | nM | 4.8 | Inhibition of IFNgamma-induced STAT3 activation in human HeLa cells expressing S... | 27352042 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27352042 | 10.1021/acs.jnatprod.6b00141 | Heat sensitive channel TRPV3 | 3 |
| 16872134 | 10.1021/np050527v | Unchecked | 1 |
| 27352042 | 10.1021/acs.jnatprod.6b00141 | Unchecked | 1 |
| 27352042 | 10.1021/acs.jnatprod.6b00141 | Signal transducer and activator of transcription 3 | 1 |
Data from ChEMBL 36 via Core Engine