Assay Detail
Binding
CHEMBL3862617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of rat TRPV3 overexpressed in HEK293 cells assessed as increase in 2-aminoethoxydiphenyl borate-induced intracellular calcium concentration by Fluo-4AM dye-based spectrofluorometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Heat sensitive channel TRPV3 (CHEMBL3879847) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.26 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3943485 | — | — | 1 | 6.77 |
| CHEMBL3890789 | — | — | 1 | 5.92 |
| CHEMBL3979367 | — | — | 1 | 5.85 |
| CHEMBL497044 | INCENSOLE | — | 1 | 5.68 |
| CHEMBL3983336 | — | — | 1 | 5.62 |
| CHEMBL3959869 | — | — | 1 | 5.36 |
| CHEMBL3899770 | — | — | 1 | 5.25 |
| CHEMBL3922508 | — | — | 1 | 5.14 |
| CHEMBL3913521 | — | — | 1 | 5.07 |
| CHEMBL3975348 | — | — | 1 | 5.06 |
| CHEMBL3948101 | — | — | 1 | 4.98 |
| CHEMBL3904515 | — | — | 1 | 4.59 |
| CHEMBL3894504 | — | — | 1 | 4.54 |
| CHEMBL29411 | THYMOL | 2.0 | 1 | 4.54 |
| CHEMBL3931428 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3943485 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3890789 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3979367 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL497044 | INCENSOLE | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3983336 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3959869 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3899770 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3922508 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3913521 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3975348 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3948101 | — | EC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3904515 | — | EC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL3894504 | — | EC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL29411 | THYMOL | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3931428 | — | EC50 | = | 30100.0 | nM | 4.52 |