Assay Detail
Toxicity
CHEMBL3864949
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Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.28 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3922390 | — | — | 1 | 5.89 |
| CHEMBL3941373 | — | — | 1 | 5.74 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.56 |
| CHEMBL3895134 | — | — | 1 | 5.53 |
| CHEMBL374047 | MOSCATILIN | — | 1 | 5.36 |
| CHEMBL3932391 | — | — | 1 | 5.35 |
| CHEMBL1276338 | — | — | 1 | 5.22 |
| CHEMBL3913394 | — | — | 1 | 4.97 |
| CHEMBL3894363 | — | — | 1 | 4.86 |
| CHEMBL3896145 | — | — | 1 | 4.84 |
| CHEMBL2409062 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3922390 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3941373 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL256147 | TILARGININE | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL3895134 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL374047 | MOSCATILIN | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3932391 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL1276338 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL3913394 | — | IC50 | = | 10720.0 | nM | 4.97 |
| CHEMBL3894363 | — | IC50 | = | 13770.0 | nM | 4.86 |
| CHEMBL3896145 | — | IC50 | = | 14530.0 | nM | 4.84 |
| CHEMBL2409062 | — | IC50 | = | 16400.0 | nM | 4.79 |