Assay Detail

CHEMBL3865097

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Reduction in plasma LPA C16:0 levels in po dosed Balb-c nu/nu mouse xenografted with human MDA-MB-231-luc cells by UPLC/MS/MS analysis

ChEMBL ↗

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Target

Mus musculus (CHEMBL375) ↗

Open DB target context

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Mus musculus (CHEMBL375) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Mus musculus

CHEMBL375

Anchored from Assay target.

Protein identity Mus musculus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Tissue	Plasma
Confidence	1 — Organism
Curated By	Autocuration

Target

Mus musculus (CHEMBL375) ↗

Type	ORGANISM
Organism	Mus musculus

Publication

Discovery of potent inhibitors of the lysophospholipase autotaxin.

Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, Hitchin JR, Stockley M, MacDonald E, Quesada MJ, Trivier E, Skeete J, Ovaa H, Moolenaar WH, Ryder H.
Bioorg Med Chem Lett (2016) 26 : 5403 -5410
PubMed 27780639 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Activity	1	-	-
EC50	1	8.10	8.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3917975	CAMBRITAXESTAT	2.0	2	8.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3917975	CAMBRITAXESTAT	EC50	=	8.0	nM	8.10
CHEMBL3917975	CAMBRITAXESTAT	Activity		-	—	-