Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3865950

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against NQO1-deficient mouse L929 cells assessed as reduction in cell viability after 72 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Mus musculus
Cell Type L929
Confidence 1 — Organism
Curated By Autocuration

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
da Cruz EHG, Silvers MA, Jardim GAM, Resende JM, Cavalcanti BC, Bomfim IS, Pessoa C, de Simone CA, Botteselle GV, Braga AL, Nair DK, Namboothiri INN, Boothman DA, da Silva Júnior EN.
Eur J Med Chem (2016) 122 : 1 -16
PubMed 27341379 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.61 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.64
CHEMBL3955548 1 6.21
CHEMBL3939072 1 6.03
CHEMBL3936933 1 5.97
CHEMBL3914323 1 5.76
CHEMBL3976115 1 5.69
CHEMBL3983169 1 5.67
CHEMBL3927935 1 5.67
CHEMBL3966682 1 5.64
CHEMBL3904272 1 5.60
CHEMBL509219 1 5.57
CHEMBL3980099 1 5.48
CHEMBL3975187 1 5.48
CHEMBL3895357 1 5.47
CHEMBL3954520 1 5.46
CHEMBL517968 1 5.43
CHEMBL3932274 1 5.42
CHEMBL3945818 1 5.42
CHEMBL2441133 1 5.38
CHEMBL2022334 1 5.29
CHEMBL3984146 1 5.27
CHEMBL3905337 1 5.26
CHEMBL3934506 1 5.14
CHEMBL3926735 1 -
CHEMBL3958444 1 -
CHEMBL3962001 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 230.0 nM 6.64
CHEMBL3955548 IC50 = 620.0 nM 6.21
CHEMBL3939072 IC50 = 940.0 nM 6.03
CHEMBL3936933 IC50 = 1060.0 nM 5.97
CHEMBL3914323 IC50 = 1740.0 nM 5.76
CHEMBL3976115 IC50 = 2040.0 nM 5.69
CHEMBL3983169 IC50 = 2150.0 nM 5.67
CHEMBL3927935 IC50 = 2150.0 nM 5.67
CHEMBL3966682 IC50 = 2300.0 nM 5.64
CHEMBL3904272 IC50 = 2500.0 nM 5.60
CHEMBL509219 IC50 = 2670.0 nM 5.57
CHEMBL3980099 IC50 = 3300.0 nM 5.48
CHEMBL3975187 IC50 = 3300.0 nM 5.48
CHEMBL3895357 IC50 = 3380.0 nM 5.47
CHEMBL3954520 IC50 = 3430.0 nM 5.46
CHEMBL517968 IC50 = 3680.0 nM 5.43
CHEMBL3932274 IC50 = 3770.0 nM 5.42
CHEMBL3945818 IC50 = 3830.0 nM 5.42
CHEMBL2441133 IC50 = 4130.0 nM 5.38
CHEMBL2022334 IC50 = 5170.0 nM 5.29
CHEMBL3984146 IC50 = 5330.0 nM 5.27
CHEMBL3905337 IC50 = 5460.0 nM 5.26
CHEMBL3934506 IC50 = 7160.0 nM 5.14
CHEMBL3926735 IC50 > 13990.0 nM -
CHEMBL3958444 IC50 > 12680.0 nM -
CHEMBL3962001 IC50 > 8670.0 nM -