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Assay Detail

CHEMBL3866602

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against mouse NIH/3T3 cells measured after 96 hrs by SRB assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Mus musculus
Cell Type NIH3T3
Confidence 1 — Organism
Curated By Autocuration

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

Selective killing of cancer cells with triterpenoic acid amides - The substantial role of an aromatic moiety alignment.
Sommerwerk S, Heller L, Kuhfs J, Csuk R.
Eur J Med Chem (2016) 122 : 452 -464
PubMed 27416552 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 5.57 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3951672 1 6.22
CHEMBL3960379 1 6.16
CHEMBL3889669 1 6.05
CHEMBL3891324 1 6.05
CHEMBL3934407 1 5.75
CHEMBL3965062 1 5.75
CHEMBL3973044 1 5.66
CHEMBL3970826 1 5.62
CHEMBL3898591 1 5.54
CHEMBL3925206 1 5.49
CHEMBL3944016 1 5.46
CHEMBL3950018 1 5.38
CHEMBL3905328 1 5.28
CHEMBL3958700 1 5.24
CHEMBL3957340 1 5.07
CHEMBL3916054 1 4.99
CHEMBL3941260 1 4.90
CHEMBL3980558 1 -
CHEMBL3779951 1 -
CHEMBL3933961 1 -
CHEMBL3972516 1 -
CHEMBL3917882 1 -
CHEMBL391534 1 -
CHEMBL482673 AUGUSTIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3951672 EC50 = 600.0 nM 6.22
CHEMBL3960379 EC50 = 700.0 nM 6.16
CHEMBL3889669 EC50 = 900.0 nM 6.05
CHEMBL3891324 EC50 = 900.0 nM 6.05
CHEMBL3934407 EC50 = 1800.0 nM 5.75
CHEMBL3965062 EC50 = 1800.0 nM 5.75
CHEMBL3973044 EC50 = 2200.0 nM 5.66
CHEMBL3970826 EC50 = 2400.0 nM 5.62
CHEMBL3898591 EC50 = 2900.0 nM 5.54
CHEMBL3925206 EC50 = 3230.0 nM 5.49
CHEMBL3944016 EC50 = 3500.0 nM 5.46
CHEMBL3950018 EC50 = 4200.0 nM 5.38
CHEMBL3905328 EC50 = 5200.0 nM 5.28
CHEMBL3958700 EC50 = 5700.0 nM 5.24
CHEMBL3957340 EC50 = 8600.0 nM 5.07
CHEMBL3916054 EC50 = 10200.0 nM 4.99
CHEMBL3941260 EC50 = 12700.0 nM 4.90
CHEMBL3980558 EC50 > 60000.0 nM -
CHEMBL3779951 EC50 > 30000.0 nM -
CHEMBL3933961 EC50 > 30000.0 nM -
CHEMBL3972516 EC50 > 30000.0 nM -
CHEMBL3917882 EC50 > 60000.0 nM -
CHEMBL391534 EC50 > 30000.0 nM -
CHEMBL482673 AUGUSTIC ACID EC50 > 30000.0 nM -