Assay Detail
ADMET
CHEMBL3867191
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Reversible inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysis
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 6.51 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419505 | — | — | 1 | 7.30 |
| CHEMBL2419504 | — | — | 1 | 7.30 |
| CHEMBL2420620 | — | — | 1 | 7.22 |
| CHEMBL3260358 | — | — | 1 | 7.16 |
| CHEMBL2391572 | — | — | 1 | 7.16 |
| CHEMBL2417572 | — | — | 1 | 7.10 |
| CHEMBL2419515 | — | — | 1 | 7.10 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 6.92 |
| CHEMBL3394738 | — | — | 1 | 6.80 |
| CHEMBL2420629 | — | — | 1 | 6.70 |
| CHEMBL3889557 | — | — | 1 | 6.70 |
| CHEMBL3394734 | — | — | 1 | 6.70 |
| CHEMBL3959982 | — | — | 1 | 6.47 |
| CHEMBL3907541 | — | — | 1 | 6.44 |
| CHEMBL3908644 | — | — | 1 | 6.40 |
| CHEMBL2391568 | — | — | 1 | 6.38 |
| CHEMBL3935485 | — | — | 1 | 6.35 |
| CHEMBL3127521 | — | — | 1 | 6.14 |
| CHEMBL3897803 | — | — | 1 | 6.00 |
| CHEMBL3891956 | — | — | 1 | 5.47 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 5.44 |
| CHEMBL3890621 | — | — | 1 | 5.41 |
| CHEMBL3902837 | — | — | 1 | 5.14 |
| CHEMBL3940454 | — | — | 1 | - |
| CHEMBL3904503 | — | — | 1 | - |
| CHEMBL3923552 | — | — | 1 | - |
| CHEMBL3974268 | — | — | 1 | - |
| CHEMBL3895553 | — | — | 1 | - |
| CHEMBL3914526 | — | — | 1 | - |
| CHEMBL3984355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419505 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2419504 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2420620 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3260358 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2391572 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2417572 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2419515 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL17289 | CHS-828 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3394738 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3889557 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3394734 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2420629 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3959982 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3907541 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3908644 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2391568 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3935485 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3127521 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3897803 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3891956 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3890621 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3902837 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3930755 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3958520 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3939767 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3977721 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3948512 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3913883 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3983716 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3986197 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3952257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2393174 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2393183 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2393163 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3986623 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3958233 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3921809 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3949594 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3916438 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3932498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3913503 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3941475 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3984355 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3914526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3895553 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3974268 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3923552 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3904503 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3940454 | — | IC50 | > | 10000.0 | nM | - |