Assay Detail
Binding
CHEMBL3875273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE preincubated for 5 mins followed by butyrylthiocholine iodide substrate addition measured after 5 mins by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.70 |
| CHEMBL3885186 | — | — | 1 | 8.09 |
| CHEMBL3884690 | — | — | 1 | 8.00 |
| CHEMBL3883432 | — | — | 1 | 7.91 |
| CHEMBL3884618 | — | — | 1 | 7.85 |
| CHEMBL3884988 | — | — | 1 | 7.78 |
| CHEMBL3884858 | — | — | 1 | 7.67 |
| CHEMBL3884154 | — | — | 1 | 6.22 |
| CHEMBL3885452 | — | — | 1 | 5.88 |
| CHEMBL3884704 | — | — | 1 | 5.78 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.74 |
| CHEMBL3883443 | — | — | 1 | 5.71 |
| CHEMBL3884254 | — | — | 1 | 5.67 |
| CHEMBL3884312 | — | — | 1 | 5.66 |
| CHEMBL3884227 | — | — | 1 | 5.62 |
| CHEMBL3884709 | — | — | 1 | 5.51 |
| CHEMBL3884195 | — | — | 1 | 5.49 |
| CHEMBL3885238 | — | — | 1 | 5.47 |
| CHEMBL3883921 | — | — | 1 | 5.21 |
| CHEMBL3883620 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3885186 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3884690 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3883432 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL3884618 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL3884988 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL3884858 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL3884154 | — | IC50 | = | 607.9 | nM | 6.22 |
| CHEMBL3885452 | — | IC50 | = | 1307.0 | nM | 5.88 |
| CHEMBL3884704 | — | IC50 | = | 1673.0 | nM | 5.78 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL3883443 | — | IC50 | = | 1951.0 | nM | 5.71 |
| CHEMBL3884254 | — | IC50 | = | 2163.0 | nM | 5.67 |
| CHEMBL3884312 | — | IC50 | = | 2211.0 | nM | 5.66 |
| CHEMBL3884227 | — | IC50 | = | 2384.0 | nM | 5.62 |
| CHEMBL3884709 | — | IC50 | = | 3071.0 | nM | 5.51 |
| CHEMBL3884195 | — | IC50 | = | 3217.0 | nM | 5.49 |
| CHEMBL3885238 | — | IC50 | = | 3394.0 | nM | 5.47 |
| CHEMBL3883921 | — | IC50 | = | 6221.0 | nM | 5.21 |
| CHEMBL3883620 | — | IC50 | = | 10550.0 | nM | 4.98 |