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Assay Detail

CHEMBL3875353

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of horse serum butyrylcholinesterase by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL5763)
Type SINGLE PROTEIN
Organism Equus caballus

Publication

New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors.
Karaman N, Sıcak Y, Taşkın-Tok T, Öztürk M, Karaküçük-İyidoğan A, Dikmen M, Koçyiğit-Kaymakçıoğlu B, Oruç-Emre EE.
Eur J Med Chem (2016) 124 : 270 -283
PubMed 27592396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.15 4.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3884922 1 4.45
CHEMBL659 GALANTAMINE 4.0 1 4.34
CHEMBL3885375 1 4.30
CHEMBL3883584 1 4.28
CHEMBL3884571 1 4.18
CHEMBL3885089 1 4.16
CHEMBL3885249 1 4.14
CHEMBL3884946 1 4.11
CHEMBL3885294 1 4.08
CHEMBL3883957 1 4.06
CHEMBL3884514 1 4.04
CHEMBL3883826 1 4.03
CHEMBL3884675 1 4.02
CHEMBL3885095 1 4.00
CHEMBL3883629 1 4.00
CHEMBL3884685 1 -
CHEMBL3885058 1 -
CHEMBL3884920 1 -
CHEMBL3885314 1 -
CHEMBL3884157 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3884922 IC50 = 35300.0 nM 4.45
CHEMBL659 GALANTAMINE IC50 = 46030.0 nM 4.34
CHEMBL3885375 IC50 = 50100.0 nM 4.30
CHEMBL3883584 IC50 = 52380.0 nM 4.28
CHEMBL3884571 IC50 = 65960.0 nM 4.18
CHEMBL3885089 IC50 = 69490.0 nM 4.16
CHEMBL3885249 IC50 = 72810.0 nM 4.14
CHEMBL3884946 IC50 = 76930.0 nM 4.11
CHEMBL3885294 IC50 = 82230.0 nM 4.08
CHEMBL3883957 IC50 = 86820.0 nM 4.06
CHEMBL3884514 IC50 = 91590.0 nM 4.04
CHEMBL3883826 IC50 = 93900.0 nM 4.03
CHEMBL3884675 IC50 = 95060.0 nM 4.02
CHEMBL3885095 IC50 = 99610.0 nM 4.00
CHEMBL3883629 IC50 = 99140.0 nM 4.00
CHEMBL3884685 IC50 = 103150.0 nM -
CHEMBL3885058 IC50 = 113440.0 nM -
CHEMBL3884920 IC50 = 110070.0 nM -
CHEMBL3885314 IC50 = 155570.0 nM -
CHEMBL3884157 IC50 = 117290.0 nM -