Assay Detail
Binding
CHEMBL3875676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatum incubated for 30 mins by liquid scintillation counting analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 7.22 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3885471 | — | — | 1 | 9.70 |
| CHEMBL3885254 | — | — | 1 | 9.40 |
| CHEMBL3883955 | — | — | 1 | 9.30 |
| CHEMBL3884161 | — | — | 1 | 8.57 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.43 |
| CHEMBL3884325 | — | — | 1 | 8.21 |
| CHEMBL3884918 | — | — | 1 | 8.11 |
| CHEMBL3884874 | — | — | 1 | 7.97 |
| CHEMBL3884183 | — | — | 1 | 7.79 |
| CHEMBL3884138 | — | — | 1 | 7.57 |
| CHEMBL3883408 | — | — | 1 | 7.55 |
| CHEMBL3883603 | — | — | 1 | 7.48 |
| CHEMBL3884994 | — | — | 1 | 7.45 |
| CHEMBL3883388 | — | — | 1 | 7.42 |
| CHEMBL3884034 | — | — | 1 | 7.42 |
| CHEMBL3884681 | — | — | 1 | 7.42 |
| CHEMBL3884066 | — | — | 1 | 7.42 |
| CHEMBL3884300 | — | — | 1 | 7.39 |
| CHEMBL3883511 | — | — | 1 | 7.39 |
| CHEMBL3884065 | — | — | 1 | 7.38 |
| CHEMBL3883942 | — | — | 1 | 7.36 |
| CHEMBL3884105 | — | — | 1 | 7.34 |
| CHEMBL3883557 | — | — | 1 | 7.34 |
| CHEMBL3884733 | — | — | 1 | 6.76 |
| CHEMBL3885003 | — | — | 1 | 6.75 |
| CHEMBL3884820 | — | — | 1 | 6.42 |
| CHEMBL3885088 | — | — | 1 | 6.30 |
| CHEMBL3883773 | — | — | 1 | 6.28 |
| CHEMBL3885016 | — | — | 1 | 6.22 |
| CHEMBL3884545 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3885471 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3885254 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL3883955 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL3884161 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL85 | RISPERIDONE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3884325 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL3884918 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL3884874 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL3884183 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL3884138 | — | Ki | = | 26.7 | nM | 7.57 |
| CHEMBL3883408 | — | Ki | = | 28.1 | nM | 7.55 |
| CHEMBL3883603 | — | Ki | = | 33.1 | nM | 7.48 |
| CHEMBL3884994 | — | Ki | = | 35.4 | nM | 7.45 |
| CHEMBL3884066 | — | Ki | = | 38.1 | nM | 7.42 |
| CHEMBL3884681 | — | Ki | = | 38.5 | nM | 7.42 |
| CHEMBL3883388 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL3884034 | — | Ki | = | 38.5 | nM | 7.42 |
| CHEMBL3884300 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL3883511 | — | Ki | = | 40.3 | nM | 7.39 |
| CHEMBL3884065 | — | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL3883942 | — | Ki | = | 43.7 | nM | 7.36 |
| CHEMBL3884105 | — | Ki | = | 45.5 | nM | 7.34 |
| CHEMBL3883557 | — | Ki | = | 45.3 | nM | 7.34 |
| CHEMBL3884733 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL3885003 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL3884820 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL3885088 | — | Ki | = | 499.0 | nM | 6.30 |
| CHEMBL3883773 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL3885016 | — | Ki | = | 595.0 | nM | 6.22 |
| CHEMBL3884545 | — | Ki | = | 648.0 | nM | 6.19 |
| CHEMBL3885327 | — | Ki | = | 777.0 | nM | 6.11 |
| CHEMBL3884885 | — | Ki | = | 808.0 | nM | 6.09 |
| CHEMBL3884619 | — | Ki | = | 845.0 | nM | 6.07 |
| CHEMBL3885211 | — | Ki | = | 916.0 | nM | 6.04 |
| CHEMBL3883960 | — | Ki | = | 914.0 | nM | 6.04 |
| CHEMBL3883495 | — | Ki | = | 953.0 | nM | 6.02 |
| CHEMBL3884209 | — | Ki | = | 1196.0 | nM | 5.92 |
| CHEMBL3885180 | — | Ki | = | 1322.0 | nM | 5.88 |
| CHEMBL3883429 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3884581 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3885152 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3883484 | — | Ki | > | 10000.0 | nM | - |