Assay Detail
Functional
CHEMBL3876631
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Phototoxicity against human HaCaT cells assessed as reduction in cell viability after irradiation with white light at 120 J/cm'2 for 20 mins by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Photodynamic effect of meso-(aryl)porphyrins and meso-(1-methyl-4-pyridinium)porphyrins on HaCaT keratinocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.90 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3883779 | — | — | 1 | 7.28 |
| CHEMBL2403179 | — | — | 1 | 7.23 |
| CHEMBL3884511 | — | — | 1 | 7.17 |
| CHEMBL432374 | — | — | 1 | 6.87 |
| CHEMBL3885394 | — | — | 1 | 6.62 |
| CHEMBL3885145 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3883779 | — | IC50 | = | 52.3 | nM | 7.28 |
| CHEMBL2403179 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3884511 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL432374 | — | IC50 | = | 135.7 | nM | 6.87 |
| CHEMBL3885394 | — | IC50 | = | 240.3 | nM | 6.62 |
| CHEMBL3885145 | — | IC50 | = | 602.0 | nM | 6.22 |