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Compound Detail

CHEMBL3885394

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C[n+]1ccc(Sc2c(F)c(F)c(-c3c4nc(c(-c5c(F)c(F)c(Sc6cc[n+](C)cc6)c(F)c5F)c5ccc([nH]5)c(-c5c(F)c(F)c(Sc6cc[n+](C)cc6)c(F)c5F)c5nc(c(-c6c(F)c(F)c(Sc7cc[n+](C)cc7)c(F)c6F)c6ccc3[nH]6)C=C5)C=C4)c(F)c2F)cc1.[I-].[I-].[I-].[I-]

Basic Information

ChEMBL ID CHEMBL3885394
Phase Preclinical
Structure Type MOL
InChI Key QIDTVZNUDCTKTR-LHGVWXAPSA-J
Parent Compound CHEMBL3990402
Active Moiety CHEMBL3990402
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

1399.3
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C68H38F16I4N8S4
MW 1906.96

Activity Summary

IC50 1 meas. best 6.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 6.62 6.62 240.3 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET IC50 = 240.3 nM 6.62 Phototoxicity against human HaCaT cells assessed as reduction in cell viability ... 27956348

Literature References

PubMed DOI Target Context # Activities
27956348 10.1016/j.bmcl.2016.11.094 No relevant target 3
27956348 10.1016/j.bmcl.2016.11.094 NON-PROTEIN TARGET 2

Data from ChEMBL 36 via Core Engine