Assay Detail
Binding
CHEMBL3878024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of equine serum butyrylcholinesterase in presence of varying butyrylthiocholine iodide substrate level preincubated for 20 mins followed by substrate addition measured every 1 min for 30 mins
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.91 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3922793 | — | — | 1 | 6.92 |
| CHEMBL3941312 | — | — | 1 | 6.68 |
| CHEMBL3921743 | — | — | 1 | 6.64 |
| CHEMBL3905115 | — | — | 1 | 6.51 |
| CHEMBL3968731 | — | — | 1 | 6.39 |
| CHEMBL3950513 | — | — | 1 | 6.35 |
| CHEMBL3894580 | — | — | 1 | 6.21 |
| CHEMBL2104722 | PICLOXYDINE | 2.0 | 1 | 6.21 |
| CHEMBL3957684 | — | — | 1 | 6.13 |
| CHEMBL3963893 | — | — | 1 | 6.02 |
| CHEMBL3949066 | — | — | 1 | 5.93 |
| CHEMBL3897572 | — | — | 1 | 5.90 |
| CHEMBL3924020 | — | — | 1 | 5.77 |
| CHEMBL3940753 | — | — | 1 | 5.75 |
| CHEMBL3978195 | — | — | 1 | 5.73 |
| CHEMBL3913329 | — | — | 1 | 5.71 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 5.68 |
| CHEMBL3975982 | — | — | 1 | 5.52 |
| CHEMBL3947927 | — | — | 1 | 5.48 |
| CHEMBL3949522 | — | — | 1 | 5.28 |
| CHEMBL3964220 | — | — | 1 | 5.17 |
| CHEMBL3959216 | — | — | 1 | 5.04 |
| CHEMBL3916022 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3922793 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3941312 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3921743 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL3905115 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3968731 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL3950513 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3894580 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL2104722 | PICLOXYDINE | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL3957684 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL3963893 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL3949066 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL3897572 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL3924020 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL3940753 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL3978195 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL3913329 | — | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | Ki | = | 2070.0 | nM | 5.68 |
| CHEMBL3975982 | — | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL3947927 | — | Ki | = | 3340.0 | nM | 5.48 |
| CHEMBL3949522 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL3964220 | — | Ki | = | 6820.0 | nM | 5.17 |
| CHEMBL3959216 | — | Ki | = | 9030.0 | nM | 5.04 |
| CHEMBL3916022 | — | Ki | = | 10780.0 | nM | 4.97 |