Assay Detail
Toxicity
CHEMBL3878512
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Cytotoxicity against human CRL-1855 cells assessed as cell viability after 48 hrs by alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CRL-1855 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.68 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.67 |
| CHEMBL3940296 | — | — | 1 | 4.85 |
| CHEMBL3963464 | — | — | 1 | 4.81 |
| CHEMBL3978033 | — | — | 1 | 4.65 |
| CHEMBL3973685 | — | — | 1 | 4.64 |
| CHEMBL3953659 | — | — | 1 | 4.53 |
| CHEMBL3920674 | — | — | 1 | 4.48 |
| CHEMBL3969840 | — | — | 1 | 4.47 |
| CHEMBL3938391 | — | — | 1 | 4.34 |
| CHEMBL3962406 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7568 | QUINACRINE | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL3940296 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3963464 | — | EC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL3978033 | — | EC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3973685 | — | EC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3953659 | — | EC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL3920674 | — | EC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL3969840 | — | EC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL3938391 | — | EC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL3962406 | — | EC50 | = | 46200.0 | nM | 4.33 |