Assay Detail
Binding
CHEMBL3880709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant pre-activated GST-tagged JNK3 (unknown origin) using biotinylated GST-tagged c-Jun as substrate after 120 mins in presence of 33gamma-ATP by beta scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzazole derivatives and their use as jnk modulators
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.77 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3947385 | — | — | 1 | 7.52 |
| CHEMBL3899711 | — | — | 1 | 7.22 |
| CHEMBL3909478 | — | — | 1 | 7.16 |
| CHEMBL3947134 | — | — | 1 | 6.98 |
| CHEMBL1991853 | — | — | 1 | 6.54 |
| CHEMBL3911431 | — | — | 1 | 6.46 |
| CHEMBL3909574 | — | — | 1 | 6.29 |
| CHEMBL399168 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3947385 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3899711 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3909478 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3947134 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL1991853 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3911431 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3909574 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL399168 | — | IC50 | = | 950.0 | nM | 6.02 |